![]() ![]() ![]() We demonstrate several applications of iTools as a framework for integrated bioinformatics. iTools employs a decentralized, portable, scalable and lightweight framework for long-term resource management. iTools is an open source project both in terms of the source code development as well as its meta-data content. The first one is based on an ontology of computational biology resources, and the second one is derived from hyperbolic projections of manifolds or complex structures onto planar discs. We propose two ways to browse and display the iTools dynamic collection of resources. Investigators or computer programs may utilize these interfaces to search, compare, expand, revise and mine meta-data descriptions of existent computational biology resources. iTools includes human and machine interfaces to its resource meta-data repository. ![]() A large number of resources are already iTools-accessible to the community and this infrastructure is rapidly growing. iTools provides a system for classification, categorization and integration of different computational biology resources across space-and-time scales, biomedical problems, computational infrastructures and mathematical foundations. The iTools design, implementation and resource meta - data content reflect the broad research, computational, applied and scientific expertise available at the seven National Centers for Biomedical Computing. Specifically, iTools stores information about three types of resources–data, software tools and web-services. We describe a new infrastructure, iTools, for managing the query, traversal and comparison of diverse computational biology resources. There is an explosion in algorithms and tools for computational biology, which makes it difficult for biologists to find, compare and integrate such resources. The advancement of the computational biology field hinges on progress in three fundamental directions – the development of new computational algorithms, the availability of informatics resource management infrastructures and the capability of tools to interoperate and synergize. ![]()
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9/6/2023 0 Comments What did helter skelter mean![]() ![]() The Beatles were not a heavy metal band, but they knew how to write rock tunes that fit their modus operandi. As it happens, neither did McCartney when he wrote the song, but Mötley Crüe rose to the occasion by recording a version that’s as punchy as the original but holds a better vocal delivery to the more plodding tune The Beatles issued out. Although Lennon makes an ample amount of errors in the track, that all plays beautifully into the raucous charm of ‘Helter Skelter’ - the track was meant to be a dirty beast, and it’s imperfections make it a perfect rock ‘n’ roll masterpiece.I bet you never thought you’d see Paul McCartney and Nikki Sixx in the same piece. Hearing his part of the song isolated confirms exactly why Beatles bass duties were better off under McCartney’s sturdy supervision. It remains unclear exactly why Lennon played bass on the track. “It sounded nothing like The Beatles,” Starr reflected. “Sometimes you just had to shake out the jams”-and they certainly did. “‘Helter Skelter’ was a track we did in total madness and hysterics in the studio,” Ringo Starr once recalled. I was happy to have Pete’s quote to get me there.” I went into the studio and told the guys, ‘Look, I’ve got this song but Pete said this and I want to do it even dirtier.’ It was a great brief for the engineers, for everyone- just as fuzzy and as dirty and as loud and as filthy as you can get it is where I want to go. ![]() “I thought, ‘Right, they’ve done what they think was the loudest and dirtiest we’ll do what we think’. “Just reading those lines (of the Townshend interview) fired my imagination,” McCartney told Mojo in 2008. ![]() So I said to the guys, ‘I think we should do a song like that something really wild.’ And I wrote ‘Helter Skelter’.” “I never actually found out what track it was that The Who had made, but that got me going just hearing him talk about it. “I was in Scotland and I read in Melody Maker that Pete Townshend had said: ‘We’ve just made the raunchiest, loudest, most ridiculous rock ‘n’ roll record you’ve ever heard,'” said Macca. ![]() ![]() ![]()
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